We make use of integrated photonics, or optical chips. These chips carry wave guides that transport light across the chip to several integrated sensors. These sensors, so-called ring resonators, are in fact extremely sensitive refractive index sensors. The binding of biomolecules on the sensor surface leads to a refractive index change. By functionalising the ring resonators with for instance an antibody, a highly sensitive and selective biosensor is obtained.
Our sensor technology has the following characteristics:
- The optical chips are inexpensive and can be used as disposables.
- The ring resonators are very small, such that many fit on a small chip surface. This allows highly-multiplexed detection.
- As result of the small chip size, small samples, such as a fingerprick, suffice.
- The instrument to read-out the sensor is an inexpensive, potentially hand-held device.
- The detection technique is label-free, which means that analytes are detected directly, without the need to attach detection labels. This enables real-time monitoring of binding kinetics.